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Acute liver failure due to fluconazole and ornidazole usage

Journal Volume 78 - 2015
Issue Fasc.1 - Letters
Author(s) Yusuf Kayar, Medine Ismailova, Sebnem Emegil, Ahmet Danalioglu, Hakan Senturk
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(1) Department of Internal Medicine, Division of Gastroenterology, (2) Department of Internal Medicine, Bezmialem Vakif University, Istanbul, Turkey.

24-year-old female patient was admitted with jaundice, itching and abdominal distention. The patient was puted on fluconazole 150 mg/day, ornidazol 1500 mg/day therapy with the diagnosis of vaginitis. On the fifth day of the treatment the patient stopped treatment because of nausea and vomiting. 15 days after the ongoing com- plaints, jaundice, pruritus and abdominal swelling was developed and the patients was hospitalized. Physical examination revealed icterus, ascites. There was no hepatosplenomegaly.

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